Reviews of what you should be reading next.

Tag: science (Page 1 of 2)

TO CURE OR KILL by Michael Young

 

This is a frightening story describing the scientific discovery of a new cancer medication, and the greed and quest for wealth within the pharmaceutical industry. The book delves into the world of scientific development, executive entitlement, and the ruthless efforts to obtain a needed molecular synthesis protocol to advance a new drug. At the end of the novel, the reader will need to ask themselves the underlying question: Is this story really fiction?

 

Thanks to Reedsy Discovery for this review copy!

In this frightening novel, author Michael Young delves into the dark side of the pharmaceutical industry, where greed and ambition clash with the pursuit of life-saving cures. The story revolves around a groundbreaking discovery of a new cancer-preventing drug and the ruthless individuals who will stop at nothing to exploit it for their own gain. The captivating narrative weaves together scientific intrigue, corporate espionage, and moral quandaries, keeping the reader interested until the very end. The novel’s exploration of the ethical boundaries of scientific research is particularly thought-provoking, raising questions about the balance between profit and human health.

The characters are complex and believable, making you care about their fate. Most of the scientists in this book are created as sympathetic characters (rather than science nerds), and the bad guys are so easy to hate! The author has done a thorough job of creating arrogant, narcissistic criminals, and I was impressed at how he was able to create a plausible story line that delved into the mind of the villains as they planned their heinous actions.

The novel is suspenseful, with plenty of twists and turns to keep you guessing. I also appreciated the accurate medical details: as a physician, Young clearly has a deep understanding of the medical field, which adds to the realism of the story. It is detailed yet easy for the layman to understand. These details may also serve to educate the reader about DNA, , mRNA, how new drugs are created, and medical ethics. There are also extensive descriptions of various poisons and how to use them for nefarious purposes.

One of the author’s strengths is the way he uses adjectives to create a picture. I particularly liked the description of the inside of a character’s home: “Burksdale made a final look around the rather boring, sullen, apartment…”. Another few sentences of note: “With his good looks, self-confidence, and obvious intelligence, Bob could walk into any room and light it up. The women adored him, and the men wanted to be him.”

I also learned some more about company security. We are all subject to phishing and identity theft, and I liked how the tone of chapter 9 was set by chapter 8’s discussing the internet of things and how hackers operate.

This book made me think about medical ethics and corporate greed. The drug companies in the United States are at times both helpful and a hindrance. Lifesaving drugs are created, yet they are ridiculously overpriced, and people may have to choose between food on the table or the medication that makes their quality of life better. It is also very frightening to consider that corporate espionage goes on every day, and we may never find out about it.

Some things I disliked about the book were: simple editing errors regarding spelling (pored over, NOT poured over!) and the author’s excessive use of italics. He used them in many instances where they were not needed. For example: italics are used for all company names (Harris Therapeutics) and websites (Google, Facebook). This became jarring to me, as I normally associate italics being used for emphasis, not to discern a company name or website, etc. Eventually I got italics fatigue and viewed it all like the boy crying wolf.

Another unpleasant idiosyncrasy I noted: the verb tenses were often not compatible with each other within the same sentence. For example, on page 69 the sentence moves from past tense to present: “…Burksdale WAS able to assemble a list….it IS frightening how much personal information IS available online…” And again, from page 73: “Traffic on the expressway CAN BE brutal during rush hour, and getting off late WOULD BE a miserable waste of time”. It was as if the author was writing an aside to the reader to make a point of explaining something. This too, became grating to me, as the English major in me cringed every time I came upon it. It took me away from being absorbed in the story to shuddering and replacing the verb tense in my mind. I have not read any other of Young’s books, so I have no way of knowing if this is a one-off in this particular book, or if that is his true writing style.

One final note: I thought the ending was a bit abrupt. I would have liked to see a little more detail about some of the characters and how their lives were affected.

In Summary: TO CURE OR KILL is a thrilling tale of greed, ambition, and the pursuit of scientific breakthroughs, with a cautionary message about the potential dangers of unchecked ambition. It is also a timely and relevant novel that sheds light on the often-hidden world of pharmaceutical research. The novel explores important themes such as the ethics of scientific research, the greed of corporations, and the power of hope. The plot is a blend of fiction and reality, and the author challenges the reader to question whether such a story could happen.

This book is a must-read for anyone interested in the intersection of medicine, business, and ethics. Fans of medical thrillers and suspenseful fiction will also enjoy this book. I recommend this book to anyone who enjoys reading the works of Robin Cook, Michael Palmer, and Sandeep Jauhar.

Want your own copy? You can pick it up here.

 

 

 

 

SAY ANARCHA by J.C. Hallman

A compelling reckoning with the birth of women’s health that illuminates the sacrifices of a young woman who changed the world only to be forgotten by it―until now.

For more than a century, Dr. J. Marion Sims was hailed as the “father of modern gynecology.” He founded a hospital in New York City and had a profitable career treating gentry and royalty in Europe, becoming one of the world’s first celebrity surgeons. Statues were built in his honor, but he wasn’t the hero he had made himself appear to be.
Sims’s greatest medical claim was the result of several years of experimental surgeries―without anesthesia―on a young, enslaved woman known as Anarcha; his so-called cure for obstetric fistula forever altered the path of women’s health.
One medical text after another hailed Anarcha as the embodiment of the pivotal role that Sims played in the history of surgery. Decades later, a groundswell of women objecting to Sims’s legacy celebrated Anarcha as the “mother of gynecology.” Little was known about the woman herself. The written record would have us believe Anarcha disappeared; she did not.

Through tenacious research, J. C. Hallman has unearthed the first evidence of Anarcha’s life that did not come from Sims’s suspect reports. Hallman reveals that after helping to spark a patient-centered model of care that continues to improve women’s lives today, Anarcha lived on as a midwife, nurse, and “doctor woman.”
SAY ANARCHA excavates history, deconstructing the biographical smoke screen of a surgeon who has falsely been enshrined as a medical pioneer and bringing forth a heroic Black woman to her rightful place at the center of the creation story of modern women’s health care.

 

Thanks to NetGalley and Henry Holt Company for this review copy!

SAY ANARCHA by JC Hallman is a remarkable work that transports readers to the haunting realities of 19th-century America, where the harrowing echoes of enslaved African American women’s lives reverberate through time. This powerful novel delves deep into the forgotten pages of history, weaving a compelling narrative that is as heart-wrenching as it is enlightening.

The story revolves around Anarcha, one of the countless enslaved women subjected to Dr. Marion Sims’ inhumane medical experiments in his quest to perfect the technique of gynecological surgery. a white doctor who is often credited with the invention of modern gynecology.

Drawing inspiration from historical events, the author masterfully combines fact and fiction, bringing the agonizing experiences of Anarcha and her fellow enslaved women to life with vivid prose. Hallman’s writing effortlessly transports readers to the 19th-century Southern United States, immersing them in a world of suffering and hope. This strength was also a weakness to me, as I felt bogged down by all the history. At one point I decided to start skipping over the incredible details and concentrate on Anarcha and the other major characters. These are my thoughts; others may welcome history as a refresher, or as new knowledge.

The book begins with a brief overview of Sims’s life and work. Sims was a brilliant surgeon, but he was also a deeply flawed man who was willing to exploit the most vulnerable members of society in his quest for medical knowledge. In 1846, Sims began performing experimental surgeries on Anarcha, who had suffered a severe vesicovaginal fistula, a condition that causes urine to leak into the vagina. Sims performed these surgeries without anesthesia, and Anarcha endured unimaginable pain and suffering. She eventually died from complications from all her surgeries.

The book is divided into two parts. The first part tells the story of Anarcha’s life, from her childhood in slavery to her years of suffering at the hands of Sims. The second part tells the story of Sims’ rise to fame as the “Father of Gynecology.” Sims’ innovations were built upon the suffering and exploitation of Anarcha and other enslaved women. Hallman weaves a vivid tapestry of historical accounts, immersing readers in the cruel reality faced by Anarcha and countless others, while shedding light on the often-neglected narratives of African American women in history.

Hallman’s book does not shy away from the horrors of Anarcha’s story. He describes in detail the surgeries that Sims performed on her, and he also explores the psychological and emotional toll that these surgeries took on Anarcha. However, Hallman also does a masterful job of humanizing Anarcha. He shows us that she was a complex and resilient woman who was determined to survive and thrive, even in the face of unspeakable cruelty. Despite the horrific abuse she suffered, Anarcha never gave up hope. She continued to fight for her freedom, and she eventually won her release from slavery.

One of the book’s strengths is the author’s ability to blend history with imagination, breathing life into Anarcha and the other characters surrounding her. Hallman’s meticulous research is evident, as he brings to light the horrors of slavery and the atrocities committed in the name of medical progress.

The novel also explores the perspectives of those around Anarcha, including Dr. Sims himself. This multi-dimensional approach adds depth to the narrative, forcing readers to confront the uncomfortable truths about the moral and ethical dilemmas faced by those complicit in perpetuating the system of slavery. The portrayal of Dr. Sims is particularly nuanced, exploring the complexity of his character as both a pioneering surgeon and a morally flawed individual. For all his knowledge, he was extremely self-centered and didn’t even care about women’s health as he was going through medical school! I feel that he did everything solely to make his name known, not out of compassion.

“Say Anarcha” may not be for the faint of heart due to its graphic descriptions of medical procedures and the harsh realities of slavery. Readers should be prepared for an emotionally intense journey that forces them to confront the uncomfortable truths of history.

Want your own copy? You can pick it up here.

 

RANDOM ACTS OF MEDICINE by Anupam B. Jena & Christopher Worsham

A groundbreaking book at the intersection of health and economics, revealing the hidden side of medicine and how unexpected—but predictable—events can profoundly affect our health. Why do kids born in the summer get diagnosed more often with A.D.H.D.? How are marathons harmful for your health, even when you’re not running? What do surgeons and salesmen have in common? Which annual event made people 30 percent more likely to get COVID-19?
As a University of Chicago–trained economist and Harvard medical school professor and doctor, Anupam Jena is uniquely equipped to answer these questions. And as a critical care doctor at Massachusetts General who researches health care policy, Christopher Worsham confronts their impact on the hospital’s sickest patients. In this singular work of science and medicine, Jena and Worsham show us how medicine really works, and its effect on all of us.

Relying on ingeniously devised natural experiments—random events that unknowingly turn us into experimental subjects—Jena and Worsham do more than offer readers colorful stories. They help us see the way our health is shaped by forces invisible to the untrained eye. Is there ever a good time to have a heart attack? Do you choose the veteran doctor or the rookie?  Do you really need the surgery your doctor recommends? These questions are rife with significance; their impact can be life changing. Addressing them in a style that’s both animated and enlightening, Random Acts of Medicine empowers you to see past the white coat and find out what really makes medicine work—and how it could work better.

 

Thanks to Doubleday Books for this review copy! Authors Anupam B. Jena and Christopher Worsham have collaborated on a fascinating and eye-opening book at the intersection of health and economics.  The book explores the surprising and often counterintuitive ways that medicine works. The authors, both doctors and researchers at Harvard Medical School, use natural experiments—random events that create natural comparisons among people—to reveal the hidden factors that influence our health outcomes.

Jena and Worsham look at medicine from a few different angles, including the role of chance and luck, the power of natural experiments, and the future of healthcare. Jena and Worsham do an excellent job of explaining complex concepts in a way that is easy to understand.

The book is divided into three parts: “The Hidden Side of Medicine,” “The Power of Natural Experiments,” and “The Future of Medicine.” In the first part, Jena and Worsham explore the ways in which chance and luck play a role in our health. They discuss how our birthdate, our zip code, and even our name can all influence our health outcomes.

In the second part of the book, Jena and Worsham introduce the concept of natural experiments. Natural experiments are events that happen outside of a doctor’s control, but which can be used to learn about the effects of different medical treatments or interventions. For example, Jena and Worsham discuss how the introduction of a new drug can be used to study the effects of that drug on a population of patients.

In the third part of the book, Jena and Worsham look at the future of medicine. They discuss how the rise of big data and artificial intelligence is changing the way we understand and treat disease. They also discuss the challenges that we face in making sure that everyone has access to high-quality healthcare.

For example, they show how kids born in the summer are more likely to be diagnosed with ADHD, how marathons can harm your health even if you don’t run, how surgeons and salesmen have similar incentives, and how an annual event made people 30 percent more likely to get COVID-19. The book is full of intriguing stories and insights that challenge our assumptions and make us think differently about medicine and health care.

The book is also written in a clear and engaging style that makes it accessible and enjoyable for anyone interested in learning more about the science and economics of medicine. The authors combine rigorous research with personal anecdotes and humor to illustrate their points and keep the reader hooked. They also offer practical advice on how to make better decisions for ourselves and our loved ones when it comes to our health. One caveat: I felt the book was a bit long. I think it could have been shorter without losing any of the valuable information.

Random Acts of Medicine is an informative read for anyone who wants to understand how medicine really works, and how it could work better. It will make you smarter, healthier, and more informed about one of the most important aspects of our lives. I recommend it to anyone who is interested in learning more about the hidden side of medicine, the power of natural experiments, and the future of healthcare.

Want your own copy? You can pick it up here. 

 

WOMB by Leah Hazard

A groundbreaking, triumphant investigation of the uterus—from birth to death, in sickness and in health, throughout history and into our possible future—from midwife and acclaimed writer Leah Hazard

The size of a clenched fist and the shape of a light bulb—with no less power and potential. Every person on Earth began inside a uterus, but how much do we really understand about the womb? Bringing together medical history, scientific discoveries, and journalistic exploration, Leah Hazard embarks on a journey in search of answers about the body’s most miraculous and contentious organ. We meet the people who have shaped our relationship with the uterus: doctors and doulas, yoni steamers and fibroid-tea hawkers, legislators who would regulate the organ’s very existence, and boundary-breaking researchers on the frontiers of the field. With a midwife’s warmth and humor, Hazard tackles pressing questions: Is the womb connected to the brain? Can cervical crypts store sperm? Do hysterectomies affect sexual pleasure? How can smart tampons help health care? Why does endometriosis take so long to be diagnosed? Will external gestation be possible in our lifetime? A clear-eyed examination of the cultural prejudices and assumptions that have made the uterus so poorly understood for centuries, Womb takes a fresh look at an organ that brings us pain and pleasure—a small part of our bodies that has a larger impact than we ever thought possible.

Thanks to NetGalley and Ecco for this review copy!

Every woman has one, but do they understand what the womb really does? Once you read this informative book you will be so happy the author wrote it.

When I saw that a midwife authored this book, I knew that it would be relevant, detailed, and female friendly. The womb is regulated by the government, dismissed by some physicians, and disparaged by men. It is also a misunderstood organ, considered to be simply the place where the fetus lives. That could not be farther from the truth! The uterus has far -reaching effects upon a woman, more than just the cause of mood swings each month during menstruation.

Each chapter discusses a different subject, such as endometriosis, hysterectomies, transplants (yes, you can put a uterus into a woman just like a heart transplant) hormones, and the various stages of the womb from first menses to menopause. The final chapters are reminiscent of BRAVE NEW WORLD, as the author discusses the possibility of an external uterus (called a biobag) and ways that a woman could be pregnant even without a womb.

There are stories in each chapter that make you realize just how much this organ is ignored and how men have used and abused it, from Josef Mengele’s experiments to the eugenics movement in the United States. Some of the details are cringeworthy, such as the woman who tried to remove her own uterus, or the story of the doctor at the Irwin County Detention Center whom they called the “uterus collector”.

Since Roe v. Wade has been overturned, women’s reproductive rights have been at the forefront of a great deal of news cycles. It seems unreal how the government, especially male politicians, have the final say on whether a woman can end her pregnancy or not. Regardless of your convictions (pro-choice or pro-life), it is unfathomable that a woman has no control over her own organs.

This book should be required reading for anyone that has a uterus. There are so many amazing facts and thought-provoking ideas – it’s almost guaranteed that you will learn something as you read WOMB. The author’s writing style is easy to understand, as she explains the science and history of this wonderful organ in a way that will make you want to keep reading.

Want your own copy? You can pick it up here.

The Truth About Animals by Lucy Cooke

Mary Roach meets Bill Bryson in this “surefire summer winner” (Janet Maslin, New York Times), an uproarious tour of the basest instincts and biggest mysteries of the animal world

Humans have gone to the Moon and discovered the Higgs boson, but when it comes to understanding animals, we’ve still got a long way to go. Whether we’re seeing a viral video of romping baby pandas or a picture of penguins “holding hands,” it’s hard for us not to project our own values–innocence, fidelity, temperance, hard work–onto animals. So, you’ve probably never considered if moose get drunk, penguins cheat on their mates, or worker ants lay about. They do–and that’s just for starters. In The Truth About Animals, Lucy Cooke takes us on a worldwide journey to meet everyone from a Colombian hippo castrator to a Chinese panda porn peddler, all to lay bare the secret–and often hilarious–habits of the animal kingdom. Charming and at times downright weird, this modern bestiary is perfect for anyone who has ever suspected that virtue might be unnatural.

Thanks to NetGalley for this review copy!

This book reads like it was written by the love child of Charles Darwin and Mary Roach. There is humor, pathos, and animal facts aplenty. The author’s writing style is easy to read and captured my attention immediately. The love Cooke has for these beasties is obvious from the start. Hopefully, given the facts, others will learn to appreciate these maligned characters that occupy the animal world.

Each chapter is devoted (lovingly) to a misunderstood animal, where we find myths debunked through modern science. The reader will learn about sloths, bats, and hyenas, to name a few. The author will discuss how the animals were experimented on/studied over hundreds of years (Who knew that Aristotle was a proponent of spontaneous creation?) then we get to modern times, where myths are debunked and the many reasons to love these animals are revealed.

Some of the experiments detailed can be a bit gory, such as when, in the 18th century, the Catholic priest Lazzaro Spallanzani practiced blinding bats to find out how they managed to find their way around in darkness. (He also coated them in varnish for another experiment, but I digress).  Other tales are edifying and satisfying, such as:

It may sound suspiciously like bogus medieval folk medicine, but from the 1940s through the 1960s the world’s first reliable pregnancy test was a small, bug-eyed frog. When injected with a pregnant woman’s urine, the amphibian didn’t turn blue or display stripes, but it did squirt out eggs 8-12 hours later to confirm a positive result.

Cooke’s book is full of factoids like that one. How can you not love this book? You will learn, you will laugh, and you will be full of obscure information. That sounds like a winner to me.

Yes, you want your own copy and can pick it up here.

The Body by Bill Bryson

In the bestselling, prize-winning A Short History of Nearly Everything Bill Bryson achieved the seemingly impossible by making the science of our world both understandable and entertaining to millions of people around the globe.

Now he turns his attention inwards to explore the human body, how it functions and its remarkable ability to heal itself. Full of extraordinary facts and astonishing stories The Body: A Guide for Occupants is a brilliant, often very funny attempt to understand the miracle of our physical and neurological make up.

A wonderful successor to A Short History of Nearly Everything, this book will have you marvelling at the form you occupy, and celebrating the genius of your existence, time and time again.

 

Thanks to NetGalley for this ARC!

Did you ever wonder how many times a day you blink? Or who invented the calorie and why we are so obsessed with counting them? These answers and a multitude of others can be found in THE BODY, a wonderfully wry book of facts and stories about, well, the body we occupy. Each chapter is devoted to one of the body’s systems (the gut, the nervous system, as well as sleep and the function of glands, etc) so as to build upon the last chapter’s information. Here’s an interesting factoid from the food chapter: fruits have been genetically manipulated to be sweeter than they were hundreds of years ago. The author purports that apples in Shakespeare’s day were no sweeter than today’s carrots.

I’m trying to decide whether Bryson’s droll wit or the abundance of information about our body is the best part of the book. You will end up learning things without even trying – there isn’t any deep scientific talk so you don’t need a degree in biology to easily read this book.

There isn’t a plot so much as a description of the body part, its function, and then facts and history about it. For example, in the chapter entitled “Gut” we learn how our digestive system works, then we learn about E. coli and other dangerous microbes, there is a bit about food safety, and then it’s 1822 and we are reading about an unfortunate accident that left a hole in a fur trapper’s stomach. This fur trapper eventually became something of a living experiment due to the injury (Google “Beaumont and St Martin” for more details if you wish).

This was an illuminating and droll read – one of the better books I have read this summer. Run, don’t walk to get your copy! You will be thoroughly enlightened and entertained, and even a bit grossed out – in a good way.

You can pick up your copy here.

 

 

Influenza by Jeremy Brown

On the 100th anniversary of the devastating pandemic of 1918, Jeremy Brown, a veteran ER doctor, explores the troubling, terrifying, and complex history of the flu virus, from the origins of the Great Flu that killed millions, to vexing questions such as: are we prepared for the next epidemic, should you get a flu shot, and how close are we to finding a cure?

While influenza is now often thought of as a common and mild disease, it still kills over 30,000 people in the US each year. Dr. Jeremy Brown, currently Director of Emergency Care Research at the National Institutes of Health, expounds on the flu’s deadly past to solve the mysteries that could protect us from the next outbreak. In Influenza, he talks with leading epidemiologists, policy makers, and the researcher who first sequenced the genetic building blocks of the original 1918 virus to offer both a comprehensive history and a roadmap for understanding what’s to come.
Dr. Brown digs into the discovery and resurrection of the flu virus in the frozen victims of the 1918 epidemic, as well as the bizarre remedies that once treated the disease, such as whiskey and blood-letting. Influenza also breaks down the current dialogue surrounding the disease, explaining the controversy over vaccinations, antiviral drugs like Tamiflu, and the federal government’s role in preparing for pandemic outbreaks. Though 100 years of advancement in medical research and technology have passed since the 1918 disaster, Dr. Brown warns that many of the most vital questions about the flu virus continue to confound even the leading experts.
Influenza is an enlightening and unnerving look at a shapeshifting deadly virus that has been around long before people—and warns us that it may be many more years before we are able to conquer it for good.

Thanks to NetGalley for the ARC!

Yes, this is another book on the influenza pandemic of 1918 – my goal is to read them all. Seriously, it is always good to compare one with the other and possibly learn new information. One new angle with this book is that the author discusses the Tamiflu controversy in detail (I wasn’t aware of the issues behind this drug, and the backstory makes the juxtaposition with the pandemic particularly chilling). Another angle is that this book is not restricted to the 1918 outbreak; there is a discussion of the virus in general, what type of research has been done, and puts forth the probability of when/how another outbreak could be possible.

One of my favorite portions of the book was the story behind the exhumed victims and how the virus was recovered from their bodies. The author’s respect for their sacrifice shines clearly through in this section, which is detailed but not gory. The gore factor is minimal, compared to other books on influenza or diseases in particular.

The fact that the author is a medical doctor means that he’s done his research and can strike the balance between med-speak and conveying his ideas to the general public. The book is very easy to read and eminently understandable. I read this over the course of a few days and it kept me interested throughout. It is always refreshing when an author can take a subject and provide a fresh, relevant look at it.

You can pick up your own copy here.

Heart: A History by Sandeep Jauhar

The bestselling author of Intern and Doctored tells the story of the thing that makes us tick

For centuries, the human heart seemed beyond our understanding: an inscrutable shuddering mass that was somehow the driver of emotion and the seat of the soul. As the cardiologist and bestselling author Sandeep Jauhar shows in Heart: A History, it was only recently that we demolished age-old taboos and devised the transformative procedures that have changed the way we live.
Deftly alternating between key historical episodes and his own work, Jauhar tells the colorful and little-known story of the doctors who risked their careers and the patients who risked their lives to know and heal our most vital organ. He introduces us to Daniel Hale Williams, the African American doctor who performed the world’s first open heart surgery in Gilded Age Chicago. We meet C. Walton Lillehei, who connected a patient’s circulatory system to a healthy donor’s, paving the way for the heart-lung machine. And we encounter Wilson Greatbatch, who saved millions by inventing the pacemaker–by accident. Jauhar deftly braids these tales of discovery, hubris, and sorrow with moving accounts of his family’s history of heart ailments and the patients he’s treated over many years. He also confronts the limits of medical technology, arguing that future progress will depend more on how we choose to live than on the devices we invent. Affecting, engaging, and beautifully written, Heart: A History takes the full measure of the only organ that can move itself.

 

Thanks to NetGalley for this ARC!

I am a big fan of the author and his writing, and HEART did not disappoint. There were many facts about the heart (some obscure, some not) interspersed throughout the book to complement patient stories. We read about the author as a young boy and his personal desire to work in cardiology, stemming from the story of a relative’s death during his formative years. The author comes across as a caring and knowledgeable doctor with a kind bedside manner – there are no veiled frustrations or jabs at ornery patients, as I have read in other medical books.

One of the best things about the book is that it’s part history, part medicine, part almost-gory-but-not-overly-done, and part philosophy. Each chapter can stand alone and be read a few days apart without having to remember the plot or which patient he is discussing. Thoughtful illustrations are added to underscore the meaning of the chapters, and footnotes are added to provide explanations or information without slowing down the flow of the narrative. The book strikes a great balance of science and interesting plot without slowing down the narrative with a lot of detail that the average reader without a medical background wouldn’t understand. For someone like me, with a medical background, there were also enough facts to keep me interested. Some books minimize details to make it easy for the reader; Jauhar does not do that. This makes his books fascinating and eminently readable.

Want your own copy? You can pick it up here.

 

Patient H.M. by Luke Dittrich

patient hm

 

In 1953, a twenty-seven-year-old factory worker named Henry Molaison—who suffered from severe epilepsy—received a radical new version of the then-common lobotomy, targeting the most mysterious structures in the brain. The operation failed to eliminate Henry’s seizures, but it did have an unintended effect: Henry was left profoundly amnesic, unable to create long-term memories. Over the next sixty years, Patient H.M., as Henry was known, became the most studied individual in the history of neuroscience, a human guinea pig who would teach us much of what we know about memory today.

Patient H.M. is, at times, a deeply personal journey. Dittrich’s grandfather was the brilliant, morally complex surgeon who operated on Molaison—and thousands of other patients. The author’s investigation into the dark roots of modern memory science ultimately forces him to confront unsettling secrets in his own family history, and to reveal the tragedy that fueled his grandfather’s relentless experimentation—experimentation that would revolutionize our understanding of ourselves.

Dittrich uses the case of Patient H.M. as a starting point for a kaleidoscopic journey, one that moves from the first recorded brain surgeries in ancient Egypt to the cutting-edge laboratories of MIT. He takes readers inside the old asylums and operating theaters where psychosurgeons, as they called themselves, conducted their human experiments, and behind the scenes of a bitter custody battle over the ownership of the most important brain in the world.

Patient H.M. combines the best of biography, memoir, and science journalism to create a haunting, endlessly fascinating story, one that reveals the wondrous and devastating things that can happen when hubris, ambition, and human imperfection collide.

 

Many thanks to NetGalley for this ARC.

This book is more than a memoir; more than an expose of the lobotomy trade; more than a poignant tale of a man whose life was largely lived in the present moment. It’s an unsettling view of a medical procedure touted as something to make willful women “compliant” and violent men “placid”. The imagery of the procedure itself is even more eerie – the author describes the hippocampus as “being sucked up” by the vacuum used to perform the surgery. Implements such as a trephine drill, a scalpel, and forceps are used to obliterate parts of the brain responsible for making each of us human. Patients vomit or sing during the surgery, their brain sending out chaotic impulses. Afterwards, they are a shell of their former self, sometimes mute, dull, or forgetful.

Patient H.M.  was the most intensively studied lobotomy “victim”, and his journey from epileptic to amnesiac is well chronicled here. Adding to the drama is that the grandfather of the author (Dr William Scofield) is the surgeon that operated on H.M.

There is backstabbing and intrigue within the medical community as well; one of H.M.’s fiercest protectors, neuroscientist Suzanne Corkin, may have destroyed much of her written notes on H.M., thereby casting a shadow over how much of her research was actually correct and reliable. It is mind boggling to learn about the amount of “experimentation” done on men and women, all in the name of advancing scientific knowledge. Consent at times was dubious, even after the Nuremberg Trials.  The doctors thought they were doing the best for these patients, but as the author puts it, their hubris and audacity changed lives not always for the better.

Towards the end of the book, there is a section on H.M.’s actual thoughts on himself and his memory. He tries to put a positive spin on things, noting that always living in the present makes things interesting. I suppose you can’t miss what you never had; but I also was very deeply touched by the portrayal of this man who underwent a lobotomy because he was desperate to end his constant seizures. Was the quality of his life made better by suctioning out parts of his brain? That’s the gist of PATIENT H.M. – there are uncomfortable questions and sometimes dubious answers that make sense at times, but in actuality heinous, unspeakable deeds were committed against innocent people.

The author does a wonderful job of forcing the reader to consider these broken people as tragic creatures, unknowing fodder (sometimes referred to as “material”) for the surgeons who were all eager to try out this new and groundbreaking procedure.

Also broken are the main characters: the surgeon Scoville, the neuroscientist Corkin, and the brain researcher Jacopo Annese, who took possession of H.M.’s brain after the famous amnesiac died. After live streaming the dissection of the brain, there followed a volatile custody battle between Corkin and Annese over who was the “real” owner of the organ. Everyone wanted a piece of H.M. , either in life or death – and akin to Henrietta Lacks, he was never truly compensated for it.

I dare you to read this book and not be moved. PATIENT H.M. is educational, thrilling, and serves as a reminder of just how far medical science has come – and the depths it has gone to in order to reach this point.

You can pick up your copy [easyazon_link identifier=”0812992733″ locale=”US” nw=”y” tag=”gimmethatbook-20″]here[/easyazon_link].

Life On The Edge by McFadden & Al-Khalili

life on the edge

 

Life is the most extraordinary phenomenon in the known universe; but how did it come to be? Even in an age of cloning and artificial biology, the remarkable truth remains: nobody has ever made anything living entirely out of dead material. Life remains the only way to make life. Are we still missing a vital ingredient in its creation?

Like Richard Dawkins’ The Selfish Gene, which provided a new perspective on how evolution works, Life on the Edge alters our understanding of our world’s fundamental dynamics. Bringing together first-hand experience at the cutting edge of science with unparalleled gifts of explanation, Jim Al-Khalili and Johnjoe Macfadden reveal that missing ingredient to be quantum mechanics; the phenomena that lie at the heart of this most mysterious of sciences.

Drawing on recent ground-breaking experiments around the world, each chapter in Life on the Edge engages by illustrating one of life’s puzzles: How do migrating birds know where to go? How do we really smell the scent of a rose? How do our genes copy themselves with such precision?Life on the Edge accessibly reveals how quantum mechanics can answer these probing questions of the universe.

Guiding the reader through the rapidly unfolding discoveries of the last few years, Al-Khalili and McFadden communicate the excitement of the explosive new field of quantum biology and its potentially revolutionary applications, while offering insights into the biggest puzzle of all: what is life? As they brilliantly demonstrate in these groundbreaking pages, life exists on the quantum edge.

Every non-fiction title must match the rigor of its investigative narrative to the weight of its message. Here is a book that seems to herald a brave new world of possible technology and depth of understanding, brought to us by the field of quantum biology. I harbor little skepticism that the authors’ chosen field of study will bring to bear significant impact upon everyday life and scientific conquest of the unknown alike. I am, however, perturbed by the willingness, even giddiness, of the authors to extend their findings into areas of study not directly related to their work, dispensing entirely with intellectual rigor in favor of the eye-catching pizazz of a History Channel or TLC docuthriller.

I wish that I could be kinder to this book, but I can’t. In my relatively short life, I’ve watched worthwhile institutions (from the Smithsonian Institute to just about every news broadcast on the tube) turn into entertainment media. What makes this book part of that media is that its takeaway is a romantic image of a scientific future and a mysterious universe, rather than the science itself. The viewer of a modern Discovery Channel program, for example, often concludes a viewing experience feeling entertained, confusing this “entertained” feeling for the feeling of having learned something. The dynamics that propagate this kind of confusion are all present in Life on the Edge:

-Examples overstay their welcome, explaining the same thing multiple ways, and appealing to different emotions each time rather than to different features of the thing being explained

-Being overly numerous, the examples replace a dearth of content and context with a breadth of verbosity.

-Phrases such as “It could be the case that…” and “Perhaps [subject] could even…” are used to extend verifiable claims grossly beyond the limits of reasonable speculation, and into a land of pure imagination. This would be fine, of course, if it did not happen in a book written by two highly credible and accomplished scientists whose word many will take as gold. By trying to extend the appeal of this book to those who are not fascinated by the wonder of the quantum world alone, the authors risk alienating those who are, their core audience.

I would recommend this book to someone who has no prior knowledge of what the phrase “quantum mechanics” means, perhaps hoping that the hyperbole it contains might ignite his or her fascination. Some say that this is a valid way to spark interest in people. However, I have always found this method to be demeaning to those upon whom it is used, like using the prospect of a career as an astronaut to entice children to become interested in the cosmos. Visionary public scientists like Carl Sagan wouldn’t treat children this way, which is partially why he is still beloved today. Other public scientists who hope to have a positive impact need to follow suit.

I received this book from Blogging For Books in exchange for this review. Want your own copy? You can pick it up [easyazon_link identifier=”0307986810″ locale=”US” nw=”y” tag=”gimmethatbook-20″]here[/easyazon_link].

 

 

 

 

 

 

 

« Older posts

© 2024 gimmethatbook

Theme by Anders NorenUp ↑